Lymph nodes are key sites for the development of tissue-specific adaptive immunity, and their spaced distribution among tissues facilitates simultaneous immune decision-making in different organs. Some lymph nodes may serve multiple organs at the same time, and these shared lymph nodes may result in the shared organs being more susceptible to immune crosstalk, and the mechanism of how the lymph nodes integrate the complex information and respond accordingly to such a scenario is still not clear. unclear.

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